Features of CpG site methylation within miRNA gene MIR10B and transcription factor gene TWIST1 in atherosclerosis
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چکیده
منابع مشابه
CpG methylation inhibits proenkephalin gene expression and binding of the transcription factor AP-2
DNA methylation at HpaII (CmCGG) sites inhibits expression of a human proenkephalin-CAT fusion gene when it is transiently expressed in CV-1 cells or stably expressed in C6-glioma cells. The inhibitory effects of HpaII methylation have been mapped to a site within the human proenkephalin promoter located at position -72 relative to the start site of transcription. This region spans a cAMP and p...
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BACKGROUND Age-related cataract (ARC) is the leading cause of visual impairment worldwide, and α-crystallin (CRYAA) is the predominant structural protein involved in the maintenance of lens clarity and refractive properties. We previously demonstrated that CRYAA genes undergo epigenetic repression in the lens epithelia in ARC. We further analyze the underlying mechanism in the current study. ...
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Methylation of cytosine-residues in the sequence CpG affects the expression of many genes and generally correlates with reduced transcription. The ribosomal genes of Xenopus laevis were among the first genes to be studied with respect to their DNA methylation, and a loss of methylation during embryonic development correlated with the onset of transcription. Nevertheless, highly methylated ribos...
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Drought, an abiotic stress, considered as one of the factors limiting food resources. The plant responses to adaptive to such a condition are accompanied with changes in the expression pattern of some functional as well as regulatory genes. The MYB proteins include a big family of transcription factors which are highly important in regulating development process and immunizing responses of plan...
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ژورنال
عنوان ژورنال: Nauchno-prakticheskii zhurnal «Medicinskaia genetika»
سال: 2020
ISSN: 2073-7998
DOI: 10.25557/2073-7998.2020.05.44-45